A global network of clinicians, academics and advocates dedicated to the elimination of mother to child transmission of syphilis.

Who are we?

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We have over 100 members on our global mailing list!

We have over 100 members on our global mailing list!

We are always looking to grow our team:

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    Collaborate

    If you are currently involved in clinical care or research of mothers or infants with syphilis and would like to collaborate on research

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    Advocate

    If you are involved in guideline or policy development around PMTCT at an institutional, national or international level and would like to engage with the network

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    Innovate

    If you are working on the development or evaluation of novel diagnostics, vaccines or treatments related to perinatal syphilis let us know.

The network is led by a Steering Committee

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    Bridget Freyne

    University College Dublin & Childrens Health Ireland Crumlin and Temple St University Hospitals, Dublin, Ireland. Department of Paediatrics, Kamuzu University of Health Sciences.

    Bridget Freyne is a paediatric infection disease specialist with a long standing interest in the management of congenital infections and particularly syphilis. She has extensive research experience in Europe and Malawi where she studied the effects of STI including syphilis on adverse outcomes and the use of rapid POCT in the diagnosis of gestational and congenital syphilis. She is the Chief Investigator of the CARES-1 clinical trial which will assess the PK and safety of oral amoxicillin and linezolid for the treatment of asymptomatic congenital syphilis in Malawi, South Africa and Indonesia

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    Michael Marks

    London School of Hygiene and Tropical Medicine) & University College London Hospital, London, United Kingdom

    Michael is Professor of Medicine at LSHTM and an adult infectious diseases clinician. He is involved in leading a portfolio of studies focused on improving control of syphilis including diagnostics, genomics and treatment trials.

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    Lisa Frigati

    Tygerberg Hospital & Stellenbosch University, Cape Town, South Africa

    Lisa Frigati is a paediatric infectious disease specialist at Tygerberg Hospital in Cape Town South Africa and an associate professor at Stellenbosch University. She has twenty years of experience in infectious diseases in resource limited setting and has a special interest in congenital infections.

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    Phoebe Williams

    University of Sydney, Australia

    Phoebe is a consultant in paediatric infectious diseases at Sydney Children’s Hospital and an NHMRC Fellow at The University of Sydney, leading a consortium across Southeast Asia (www.neoseap.com) working to reduce the burden of antibiotic resistance, and improve the prevention and management of infections in newborn babies.

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    Hermione Lyall

    Imperial College Healthcare NHS Trust, and Imperial College

    I am a consultant in paediatric infectious diseases at Imperial College Healthcare NHS Trust and Professor of Practice at Imperial College. I lead the congenital infection clinics at St Mary’s Hospital, London.  In 2020, with colleagues from around Europe, we set up CCMVNET ccmvnet@gmail.com an international network built around a prospective registry for children with congenital CMV (CCMV). I am a member of the Paediatric European Infection Network (PENTA-ID) and have participated in many HIV treatment and prevention trials for children. I have been actively involved in education for Paediatric Infections for many years, working with PENTA and the European Society for paediatric Infectious Diseases (ESPID).

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    Cristina Barroso Hofer

    Universidade Federal do Rio de Janeiro

    I am a professor of Infectious Diseases at the Universidade Federal do Rio de Janeiro Medical School. I work as a physician in the infectious diseases pediatrics and pregnant women clinic, leading the congenital infectious diseases clinic.  I am a member of the Paediatric European Infection Network (PENTA-ID):I participate on the network and engagement committee and pregnancy and vertical transmission working group. I am a voting member of the International Maternal Pediatric and Adolescent AIDS Clinical Trial network (IMPAACT)  treatment committee, and the principal investigator of the Universidade Federal do Rio de Janeiro IMPAACT site. I am involved for several years in clinical practice and research on congenital infection, including syphilis.

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    Nina Dwi Putri

    University of Indonesia, Cipto Mangunkusumo Hospital, Indonesia

    Nina is consultant of pediatric and tropical infections at Cipto Mangunkusumo Hospital, national referral hospital in Indonesia and lecturer at University of Indonesia. I am working mostly in neonatal infection and leading the Neocol project in Indonesia. My aim is to help reduce neonatal mortality through providing evidence for infection prevention and management.

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    Amanda Gwee

    Murdoch Children’s Research Institute; University of Melbourne 

    A/Prof Amanda Gwee is the Leader of the Antimicrobials Group at Murdoch Children's Research Institute. She is a general paediatrician, infectious diseases physician, clinical pharmacologist, and Clinical Lead of Research in the Department of General Medicine at The Royal Children’s Hospital Melbourne. In addition, she is an Associate Professor in the Department of Paediatrics, at the University of Melbourne. Her research program focuses on optimising antimicrobial use and access in children and includes national and international clinical trials, pharmacokinetic/pharmacodynamic studies, and cohort studies. Amanda is passionate about improving medication use in children and is involved in several international guideline/expert groups (European Society for Paediatric Infectious Diseases, WHO, Therapeutic Guidelines).

Mission and Vision

Congenital syphilis remains a significant public health challenge, disproportionately affecting low- and middle-income countries. Without adequate treatment of mothers and infants the disease can have devastating consequences, including stillbirth, neonatal death, and severe lifelong disabilities. Despite global targets to eliminate mother-to-child transmission of syphilis, progress has been limited and is hampered by limited access to adequate diagnostics and treatment.

In 2022 the World Health Organization estimated that there were more than 700,000 cases of congenital syphilis worldwide including 355,000 adverse birth outcomes. 

The Prevent Syphilis Network has been founded to bring together academics, clinicians and researchers to address these challenges. Central to this we will support, develop and deliver research studies to address critical knowledge gaps and engage with global stakeholders to advocate for sustainable investment in syphilis control.

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Events:

April 2024: Prevent Syphilis Representation at the NIH/NIAID workshop on alternative antibiotics for the treatment of congenital syphilis. 

Bridget Freyne, Lisa Frigati, Michael Marks and Oriol Mitja participated in a 2 day workshop in Washington USA. This workshop organised by NIAID brought together leading researchers from the US and internationally to discuss the current knowledge gaps with respect to penicillin-sparing regimens for the management of syphilis. The workshop was preceded by several pre-meetings with sub-groups covering topics related to pregnancy, congenital syphilis, diagnostics and translational research. The workshop reviewed the available PK and safety data for alternative antibiotics in different populations and explored the trial designs which might be useful to evaluate these options further.

December 2024: Prevent Syphilis team members receive funding from the Gates Foundation for two clinical trials in perinatal syphilis.

The STOP trial (CI: Michael Marks, LSHTM): Single Dose Penicillin Strategies for the management of syphilis in Pregnancy will recruit pregnant women in Zimbabwe and Papua New Guinea and evaluate the use of single dose subcutaneous penicillin infusion for the treatment of syphilis in pregnancy.

The CARES-1 study (CI Bridget Freyne): Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis is an open label phase II PK/PD study of oral amoxicillin and linezolid for the management of asymptomatic congenital syphilis. Infants will be recruited in South Africa (Lisa Frigati, Adrie Bekker), Indonesia (Nina Dwi Putri, Phoebe Williams), Malawi (Kondwani Kawaza, Luis Gadama, Linda Mipando and Mary McCauley) in collaboration with PK expertise from Amanda Gwee (MCRI, University of Melbourne) and Tim Cressey (PHPT-AMS Thailand) and clinical trial support from the MRC CTU (Anna Turkova, Deborah Ford). The trial will be sponsored by the London School of Hygiene and Tropical Medicine (Michael Marks, Sarah Prentice).

Publications

Projects

Currently the Prevent Syphilis Network is leading two large, multi-country trials aimed at improving treatment of syphilis in both pregnant women and infants. 

Single Dose Penicillin Treatment Strategies for Syphilis in Pregnancy (STOP TRIAL)

The STOP trial aims to evaluate if we can simplify treatment of pregnant women with syphilis through the use of an innovative subcutaneous dosing strategy. The study will run in two phases combining an initial pharmacokinetic study in healthy adults followed by a clinical trial enrolling pregnant mothers in Zimbabwe and Papua New Guinea. The project is funded by the Gates Foundation and the project will run between 2024-2028.

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The STOP consortium includes partners at the London School of Hygiene & Tropical Medicine, the Fight Infection Foundation, The Kids Institute, The Papua New Guinea Institute of Medical Research, the Biomedical Research & Training Institute, University College Dublin and Stellenbosch University. 

Comprehensive Ambulatory Antibiotics for the TReatment of Congenital Syphilis (CARES-1 Trial).

The CARES-1 trial aims to identify novel oral therapies that can be used to treat infants with congenital syphilis. The study will enroll children in Indonesia, Malawi, and South Africa and evaluate three treatment strategies including oral amoxicillin, oral linezolid and single dose benzathine-penicillin. The project is funded by the Gates Foundation and the project will run between 2024-2027.

The CARES consortium includes partners at University College Dublin, Stellenbosch University, the London School of Hygiene & Tropical Medicine, University College London, The Murdoch Children’s Research Institute, the Malawi-Liverpool Wellcome Trust, University of Sydney and Universitas Indonesia.

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